期刊论文

中文

针刺研究

1000-0607

2023

48

10

977-985

10.13702/j.1000-0607.20230233

No.82205255:国家自然科学基金 No.2022JJ40312:湖南省自然科学基金项目 2022JJ40301:湖南省自然科学基金项目

本校为第一机构

目的：观察电针对骶上脊髓损伤（SSCI）后逼尿肌反射亢进型大鼠尿流动力学及脊髓组织中丝氨酸/苏氨酸蛋白激酶（Raf）与丝裂原活化的细胞外信号调节激酶（MEK）及细胞外信号调节激酶1/2(ERK1/2)信号通路的影响，探讨电针改善SSCI后逼尿肌反射亢进型大鼠膀胱功能的可能机制。方法：72只SD大鼠随机分为空白组和假手术组各12只，其余48只大鼠采用脊髓横断法造模，在符合模型标准的大鼠中随机抽取36只分为模型组、电针组和电针+PD98059组各12只。电针组大鼠于“次髎”“中极”“三阴交”“大椎”给予电针治疗，20 min/次，1次/d，连续7 d；电针+PD98059组大鼠在同样电针干预前2 h给予腹腔注射PD9805...

OBJECTIVES: To observe the effect of electroacupuncture (EA) on urodynamics and Raf/MEK/ERK signaling pathway in spine cord tissue of rats after suprasacral spinal cord injury (SSCI), so as to explore its possible mechanism in improving bladder function in rats with detrusor hyperreflexia after SSCI. METHODS: Female SD rats were randomly divided into blank, sham operation, model, EA and EA+PD98059 groups, with 12 rats in each group. Thorax (T) 10 spinal cord transection was performed by surgery. Rats in the EA group were given EA (10 Hz/50 Hz, 20 min) at "Ciliao" (BL32), "Zhongji" (CV3), "Sany...