期刊论文

The Effect of Yiqipingxuan Beverage on the Expression of IL-2 and TGF-β1 mRNA in Implanting Lewis Lung Cancer among Mice

中文

湖南中医药大学学报

1674-070X

2004

24

6

18-20

10.3969/j.issn.1674-070X.2004.06.006

国家中医药管理局基金资助 （ 0 2 -0 3JP3 0 ）； 湖南省自然科学基金资助 （ 0 1JJ2 0 3 7）；

本校为第一机构

目的探讨益气平悬饮(YQPXB)对小鼠Lewis肺癌组织细胞中白细胞介素(IL-2)、转化生长因子(TGF-β1)表达的影响.方法 皮下接种Lewis肺癌的C57BL /6 J小鼠40只,随机分为益气平悬饮大剂量组、小剂量组、环磷酰胺对照组、荷瘤对照组,给药10 d后处死,用逆转录PCR法测定各组Lewis肺癌组织细胞中IL-2、TGF-β1 mRNA表达.结果 YQPXB大、小剂量组Lewis肺癌组织细胞中IL-2 mRNA表达水平明显高于模型组和化疗组(P＜0.01),YQPXB大、小剂量组之间无显著性差异.YQPXB大、小剂量组TGF-β1 mRNA表达水平明显低于模型组和化疗组(P＜0.01),YQPXB大、小剂量组之间无显著性差异.结论 YQPXB能促进小鼠Lewis肺癌组织细胞...

Objective To investigate the effect of Yiqipingxuan Beverage (YQPXB) on the expression of interleukin-2 (IL-2) and transforming growth factor-β 1(TGF-β 1) mRNA in the tissues of implanting Lewis lung cancer among mice. Methods 40 C 57BL?/6?J mice were implanted with the cells of Lewis lung cancer by subcutaneous injection.Then, they were randomly divided into YQPXB groups at high dose and low dose, cyclophosphamide control group and tumor-bearing control group.All mice were sacrificed ten days after drug administration.The expression of IL-2 ...