Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro

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成果类型：

期刊论文

作者：

Wei, Shanshan;Ma, Wanjun;Yang, Yuanying;Sun, Taoli;Jiang, Chuanhao;...

通讯作者：

Zhang, Bikui;Li, WQ

作者机构：

[Yang, Yuanying; Zhang, Bikui; Li, Wenqun; Wei, Shanshan; Liu, Jian] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

[Yang, Yuanying; Wei, Shanshan; Liu, Jian; Li, Wenqun; Zhang, Bikui] Cent South Univ, Inst Clin Pharm, Changsha 410011, Hunan, Peoples R China.

[Yang, Yuanying; Ma, Wanjun; Wei, Shanshan; Liu, Jian; Li, Wenqun; Zhang, Bikui] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430022, Peoples R China.

[Sun, Taoli] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Hunan, Peoples R China.

[Jiang, Chuanhao] Cent South Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Zhang, BK; Li, WQ ] C

Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Cardiotoxicity;Doxorubicin;NLRP3 inflammasome;Oxidative stress;Trastuzumab

期刊：

Biochemical Pharmacology

ISSN：

0006-2952

年：

2023

卷：

214

页码：

115662

DOI：

10.1016/j.bcp.2023.115662

基金类别：

National Natural Scientific Foundation of China [82173911, 81973406]; Hunan Provincial Innovation Foundation For Postgraduate [CX20220326]; Fundamental Research Funds for the Central Universities of Central South University [2022ZZTS0243]; Hunan Provincial Natural Scientific Foundation [2023JJ30761, 2023JJ30802]; Scientific Research Project of Hunan Provincial Health and Family Planning Commission [202113050843]; Chinese Pharmaceutical Association Hospital Pharmacy department [CPA-Z05-ZC-2021-002]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Trastuzumab (Tra), the first humanized monoclonal antibody that targets human epidermal growth factor receptor 2 (HER2), is commonly used alongside doxorubicin (Dox) as a combination therapy in HER2-positive breast cancer. Unfortunately, this leads to a more severe cardiotoxicity than Dox alone. NLRP3 inflammasome is known to be involved in Dox-induced cardiotoxicity and multiple cardiovascular diseases. However, whether the NLRP3 inflammasome contributes to the synergistic cardiotoxicity of Tra has not been elucidated. In this study, primary n...

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Trastuzumab potentiates doxorubicin-induced cardiotoxicity via activating the NLRP3 inflammasome in vivo and in vitro

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