Celastrol attenuates renal injury in diabetic rats via MAPK/NF-kappa B pathway

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成果类型：

期刊论文

作者：

Zhang, Min;Chen, Yan;Yang, Mei-ju;Fan, Xin-Rong*;Xie, Hui;...

通讯作者：

Yan, Miao;Fan, Xin-Rong

作者机构：

[Yan, Miao; Zhang, Min] Cent S Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

[Fan, Xin-Rong; Chen, Yan; Yang, Mei-ju; Zhang, Min] China Acad Chinese Med Sci, Inst Basic Theory Chinese Med, Beijing 100700, Peoples R China.

[Zhang, Min] Shaanxi Univ Chinese Med, Clin Med Coll 1, Xianyang, Peoples R China.

[Nie, Yu-Song; Fan, Xin-Rong; Zhang, Ling; Xie, Hui] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Yan, Miao; Fan, Xin-Rong] C

Cent S Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.

China Acad Chinese Med Sci, Inst Basic Theory Chinese Med, Beijing 100700, Peoples R China.

语种：

英文

关键词：

MAPK/NF-kappaB;celastrol;diabetic;renal protection

期刊：

Phytotherapy Research

ISSN：

0951-418X

年：

2019

卷：

期：

页码：

1191-1198

DOI：

10.1002/ptr.6314

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81373708, 81573686]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

The purpose of this study was to investigate the renal protective effect of celastrol on diabetic rats. Furthermore, the mechanism of its action was discussed whether it was related to MAPK/NF-kappaB signaling pathway. There were a total of 36 rats. Six rats were randomly chosen as the control group. The remaining 30 rats were given 1% streptozotocin intraperitoneal injection (50 mg/kg) and were randomly divided into five groups: the model control group, the low-dose celastrol group, the high-dose celastrol group, the Tripterygium wilfordii polyglycosides group, and the MAPK/NF-kappaB inhibito...

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Celastrol attenuates renal injury in diabetic rats via MAPK/NF-kappa B pathway

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