National Natural Science Foundation of People's Republic of ChinaNational Natural Science Foundation of China (NSFC) [81503442, 81603470]; research project of Hunan Provincial Department of Education [17B197, 16B196]
机构署名：
本校为第一且通讯机构
院系归属：
医学院
摘要：
Adipose stem cell (ASC) transplantation is a promising therapeutic strategy for diabetic renal fibrosis. Hypoxia-inducible factor 1 alpha (HIF1 alpha) is a negative regulatory factor of mitochondrial function. In the current study, we aimed to explore if HIF1 alpha deletion protects against hyperglycemia-induced ASC damage and enhances the therapeutic efficiency of ASCs in diabetic renal fibrosis. Our data indicated that HIF1 alpha was upregulated in ASCs in response to high glucose stimulation. Higher HIF1 alpha expression was associated with ASC apoptosis and proliferation arrest. Loss of HI...
