期刊论文

中文

中国实验动物学报

1005-4847

2004

12

3

177-179

10.3969/j.issn.1005-4847.2004.03.012

国家自然科学基金 （No .3 0 2 7163 3 ）； 湖南省社会发展重大项目 （NO .0 1SSY10 0 2 -4 ）；

本校为其他机构

目的探讨基质金属蛋白酶1、9在炎性子宫出血中的作用.方法运用免疫组化链霉素抗生物素蛋白-过氧化物酶染色法(SP)检测细菌感染性子宫出血恒河猴模型组子宫内膜组织中基质金属蛋白酶1、9( MMP-1、MMP-9)及其抑制剂(TIMP-1)的表达,用正常恒河猴子宫内膜作对照.结果模型组子宫内膜组织间质、腺上皮中MMP-1、9的表达明显高于正常对照组,而TIMP-1的表达与正常组水平相似.结论基质金属蛋白酶-1、9的高度表达可能与炎症导致的异常子宫出血有关.

Objective To explore the influences of MMP-1,MMP-9 on metrorrhagia induced by bacterial infection in experiment Rhesus monkey. Methods The immunohistochemical S-P were performed to estimate express level of MMP-1,9 and TIMP-1 in the endometrium of model group and normal control group. Result Compared with control group, MMP-1 and MMP-9 were much expressed in endometrial stroma and gland and TIMP-1 are expressed similarly. Conclusion The over-expression of MMP-1,9 may participate...