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Lianqinjiedu decoction attenuates LPS-induced inflammation and acute lung injury in rats via TLR4/NF-κB pathway

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成果类型:
期刊论文
作者:
Deng, Guiming;He, Hai;Chen, Zheng*;OuYang, Linqi;Xiao, Xiaoqin;...
通讯作者:
Chen, Zheng;Cheng, SW
作者机构:
[Xiang, Biao; Deng, Guiming; He, Hai; Chen, Zheng; Jiang, Sichen; OuYang, Linqi] Hunan Univ Chinese Med, Affiliated Hosp 1, Changsha 410007, Hunan, Peoples R China.
[Cheng, Shaowu; Ge, Jinwen; Xiao, Xiaoqin] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.
[Chen, Zheng; Cheng, SW] 300 Xueshi Rd Hanpu Sci & Technol Pk, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Chen, Z; Cheng, SW ] 3
300 Xueshi Rd Hanpu Sci & Technol Pk, Changsha 410208, Hunan, Peoples R China.
语种:
英文
关键词:
LianQinJieDu decoction;Lipopolysaccharide;Acute lung injury;Inflammation;TLR4/NF-κB pathway
期刊:
Biomedicine & Pharmacotherapy
ISSN:
0753-3322
年:
2017
卷:
96
页码:
148-152
基金类别:
This study was supported by the Science Foundation for the Education Commission of Hunan Province (NO. 17 C 1211) and the research Fund for Special Projects of Postdoctoral of Science and Technology Department of Hunan Province (NO.2014RS4013).
机构署名:
本校为第一机构
院系归属:
第一中医临床学院
摘要:
Acute lung injury (ALI) and its severe form acute respiratory distress syndrome remain the leading cause of morbidity and mortality. LianQinJieDu (LQJD), which is a traditional Chinese medicine, has been clinically used for antiviral drug. The present study investigated whether Lianqinjiedu(LQJD) ameliorates lipopolysaccharide (LPS)-induced acute lung injury in rats and aimed to determine the anti-inflammatory effects of LQJD. Rat model with ALI induced by intraperitoneal injection of LPS was treated by oral administration of LQJD. The recruitment of body temperature and the histopathology of ...

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