IMM-H004 protects against oxygen-glucose deprivation/reperfusion injury to BV2 microglia partly by modulating CKLF1 involved in microglia polarization.

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成果类型：

期刊论文

作者：

Chen, Chen;Ai, Qidi;Chu, Shifeng;Zhang, Zhao;Zhou, Xin;...

通讯作者：

Chen, Naihong

作者机构：

[Ai, Qidi; Chen, Chen; Chen, Naihong; Zhou, Xin; Zhang, Zhao; Chu, Shifeng] Chinese Acad Med Sci, Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Ai, Qidi; Chen, Chen; Chen, Naihong; Zhou, Xin; Zhang, Zhao; Chu, Shifeng] Chinese Acad Med Sci, Peking Union Med Coll, Neurosci Ctr, Beijing 100050, Peoples R China.

[Ai, Qidi; Chen, Naihong; Liu, Yingjiao; Luo, Piao] Hunan Univ Tradit Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Chen, Naihong] Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med,Neurosci Ctr, 1 Xiannongtan St, Beijing 100050, Peoples R China.

通讯机构：

[Chen, Naihong] C

Chinese Acad Med Sci, Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med,Neurosci Ctr, 1 Xiannongtan St, Beijing 100050, Peoples R China.

语种：

英文

关键词：

BV2 microglia;CKLF1;IMM-H004;Microglia polarization;OGD/R

期刊：

International Immunopharmacology

ISSN：

1567-5769

年：

2019

卷：

期：

页码：

69-79

DOI：

10.1016/j.intimp.2019.02.012

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81730093, 81730096, 81873026, U1402221]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-12M-1-004]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]; State Key Laboratory Fund Open Project [GTZK201610]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2013M540066]; State Administration of Traditional Chinese Medicine [60011000]; Hunan Provincial Key Laboratory for Standardization of Important Chinese Herbal Pieces [BG201701, 4981-0901020]; NDRC [60011000]; National Mega-project for Innovative Drugs [2018ZX09711001-002-007, 2018ZX09711001-003-005, 2018ZX09711001-009-013]

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本校为其他机构

摘要：

Background: IMM-H004 is a novel compound that has been shown to protect against cerebral ischemia/reperfusion injury in our previous works. Chemokine-like factor 1 (CKLF1) is a chemokine that exhibits increased expression in the ischemic brain. Dysregulation of microglia polarization dynamics is a mechanism of injury expansion poststroke. Purposes: The aim of present study was to investigate the effects of IMM-H004 on cell viability and microglia phenotypes in BV2 microglia suffering from oxygen-glucose deprivation/reperfusion and discussing th...

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IMM-H004 protects against oxygen-glucose deprivation/reperfusion injury to BV2 microglia partly by modulating CKLF1 involved in microglia polarization.

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