期刊论文

Research Progress on Chemical Constituents, Pharmacology and Hepatoxicity of Raw, Processed and Fermented Polygonum multiflorum Thunb

中文

中药新药与临床药理

1003-9783

2018

29

5

661-672

10.19378/j.issn.1003-9783.2018.05.022

国家自然科学基金青年基金项目（81503238） 国家中医药管理局中医药行业科研专项（201407003） 湖南省“十二五”重点学科药学学科资助项目（湘教发[2011]76号） 长沙市科技计划重点项目（k1406030-31） 湖南省教育厅一般项目（17C1213）

本校为第一机构

何首乌为蓼科植物何首乌Polygonum multiflorum Thunb.的干燥块根。何首乌含有蒽醌类、二苯乙烯苷类、黄酮类、磷脂类等多种类型的活性成分,具有抗衰老、增强免疫功能、降血脂、补血、抗动脉粥样硬化、抗菌等多方面的药理作用。何首乌肝毒性的临床案例报道日渐增多,其安全性备受关注。通过对生/制/发酵何首乌的化学成分、药理作用及肝毒性进行系统综述,为何首乌深度开发利用提供参考。

Polygoni multiflori radix is the root of Polygonum multiflorum Thunb. of Polygonaceae. There are many active chemical constituents in P. multiflorum, such as quinines, stilbenes, flavones, and phosphor lipids. P. multiflorum has many biological activities, includes anti- aging, hypolipidemic and anti- atherosclerosis effects. However,an increasing number of recently published studies have demonstrated the hepatoxicity of P. multiflorum, which draws attention of public. In this review, we provide a systematic comparison between P. multiflorum and related processed products in chemical constitue...