期刊论文

Effects of Chan Long Zhentong Paste on Pain Threshold and Serum Levels of PGE_2,TNF-α,IL-6 and β-EP in Bone Metastatic Cancer Pain Model Rats

中文

中药新药与临床药理

1003-9783

2019

30

10

1222-1227

10.19378/j.issn.1003-9783.2019.10.011

湖南省科技厅重点研发项目(2016SK2051).

本校为第一机构

目的探讨蟾龙镇痛膏对骨转移性癌痛大鼠模型的镇痛作用及其作用机制。方法将40只雌性SD大鼠随机分为空白组、模型组、蟾龙镇痛膏组(0.56 mg·kg~(-1))、扶他林组(0.08 mg·kg~(-1)),每组10只。除空白组外,其余各组大鼠右后肢胫骨注射Walker256乳腺癌肿瘤细胞悬液,建立骨癌痛大鼠模型。造模后14 d开始外敷相应药物,每日1次,连续21 d。观察各组大鼠疼痛缩足反射潜伏期(PWL)和缩足反射阈值(PWT),通过HE染色、X线检查评价骨癌痛大鼠模型,并用酶联免疫吸附测定法(ELISA)检测血清前列腺素E2(PGE_2)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、β内啡肽(β-EP)水平。结果模型组、蟾龙镇痛膏组、扶他...

Objective To explore the analgesic effect and possible mechanism of Chan Long Zhentong paste(CZP) in bone metastatic cancer pain model rats. Methods Forty female SD rats were randomly divided into control group, model group, CZP group and Voltaren group, with 10 rats in each group. Except the control group, rats in the other groups were injected with Walker256 breast cancer cell suspension in the right hind limb to establish the bone metastatic cancer pain model. Drugs treatments were started on the 14th day after surgery,once a day for 21 days...