期刊论文

Effects of Compound Qi Shao Jiangya Tablet on Expression of P2Y6, MEK1/2, ERK1/2 and Vascular Remodeling Marker MMP-9, TIMP-1 Proteins in SHR Rats

中文

中药新药与临床药理

1003-9783

2020

31

02

156-162

10.19378/j.issn.1003-9783.2020.02.006

201910:湖南省中医药局重点项目 2018SK51203:湖南省科技厅项目 :中医内科重大疾病防治 ZYNK201703:教育部重点实验室开放基金 2018CX37:创新基金 81473616:国家自然科学基金

本校为第一机构

目的研究复方七芍降压片对自发性高血压大鼠(SHR)肠系膜动脉中G蛋白偶联受体P2Y6、酪氨酸激酶受体(MEK1/2)、丝裂原活化蛋白激酶(ERK1/2)及血管重塑标志物基质金属蛋白酶-9(MMP-9)、组织基质金属蛋白酶抑制剂-1(TIMP-1)等蛋白表达的影响,探讨复方七芍降压片干预血管重塑的作用机制。方法将雄性SHR大鼠随机分为模型组、厄贝沙坦片组(13.5 mg·kg~(-1))、复方七芍降压片组(8.73 g·kg~(-1)),每组10只,另设10只WKY大鼠为正常对照组;灌胃给药,每日1次,连续给药6周。采用无创血压仪测定每周大鼠尾动脉血压;ELISA法检测大鼠血清中白细胞介素-1β(IL-1β)水平;免疫组化法检测肠系膜动脉中P2Y6、MEK1/2、...

Objective To study the effects of compound Qi Shao jiangya tablet on the expression of P2Y6,MEK1/ 2,MMP-9, TIMP-1 and ERK 1/2 related proteins in mesenteric artery of SHR rats, and to explore the mechanism of action of compound Qi Shao jiangya tablet on vascular remodeling. Methods Thirty SPF grade male SHR rats were randomly divided into three groups: model group, irhesartan tablet group (13.5 mg · kg~(-1)) arid compound Qi Shao jiangya tablet group (8.73 g · kg~(-1)) , and 10 WKY rats were used as normal control group. Blood pressure of cau...