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Polygonatum polysaccharide ameliorates D-galactose-induced cognitive dysfunction in aging rats by inhibiting ferroptosis through activation of Nrf2

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成果类型:
期刊论文
作者:
Xiao, Lan;Wen, Huiqiao;Peng, Sha;Chen, Bowei;Tang, Biao;...
通讯作者:
Liu, BY
作者机构:
[Xiao, Lan; Peng, Sha] Hunan Univ Tradit Chinese Med, Sch Pharm, Changsha, Peoples R China.
[Tang, Biao] Hunan Univ Tradit Chinese Med, Sch Med, Changsha, Peoples R China.
[Liu, Baiyan; Liu, BY; Chen, Bowei] Hunan Acad Chinese Med, Changsha, Peoples R China.
[Wen, Huiqiao] Hunan Univ Tradit Chinese Med, XiangXing Coll, Changsha, Peoples R China.
通讯机构:
[Liu, BY ] H
Hunan Acad Chinese Med, Changsha, Peoples R China.
语种:
英文
关键词:
Aging;Antioxidant;Cognitive impairment;D-galactose;Ferroptosis;Glutathione;Hippocampus;Iron;Oxidative stress;Polygonatum polysaccharide
期刊:
Neuroscience Letters
ISSN:
0304-3940
年:
2024
卷:
836
页码:
137873
基金类别:
This work was supported by the National Natural Science Foundation of China (No. 82204924); Hunan Province Postgraduate Scientific Research Innovation Project (CX20220773); Hunan Provincial Department of Education general project (22C0195). CRediT authorship contribution statement Lan Xiao: acquisition, Data curation. Huiqiao Wen: Writing – original draft. Sha Peng: Methodology, acquisition. Bowei Chen: Investigation. Biao Tang: Visualization, Supervision. Baiyan Liu: Writing – review & editing, Supervision.
机构署名:
本校为第一机构
院系归属:
医学院
药学院
湘杏学院
摘要:
Context Aging is a major risk factor for various neurodegenerative diseases, and ferroptosis has been identified as an important mode of cell death during accelerated aging. As the main component of the edible plant YuZhu in China, Polygonatum polysaccharide (POP) is an important natural compound with anti-aging properties. Aging is a major risk factor for various neurodegenerative diseases, and ferroptosis has been identified as an important mode of cell death during accelerated aging. As the main component of the edible plant YuZhu in China, Polygonatum polysaccharide (POP) is an important n...

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