期刊论文

Study Progress of Autophagy and Exosomes in Acute Lung Injury

中文

激光生物学报

1007-7146

2018

27

6

498

10.3969/j.issn.1007-7146.2018.06.002

中国博士后科学基金面上项目(2015M580690) 干细胞中药调控实验室开放项目(2013GXB02) 湖南省大学生研究性学习与创新性实验计划项目(2015)。

本校为第一机构

急性肺损伤(ALI)是一种常见的临床疾病, 在全世界范围内引起严重的健康问题, 但其发病机理尚不清楚。自噬(autophagy)是当前生物医学研究热点之一, 涉及了多种病理生理过程。近期研究表明, 自噬与包含ALI在内的多种肺部疾病的发病进展有关。外泌体(exsome)是由多种活细胞分泌的, 由脂质双层被膜包围的纳米级结构(30~100 nm)。它通过传递其囊泡内包含的蛋白质, 脂质和核酸来调节细胞间通讯和相互作用。外泌体的存在对其供体细胞、受体细胞、以及细胞间结构都有着重要的生理和病理意义。因此, 外泌体的功能及特点得到越来越多的关注, 成为疾病的诊断和治疗策略发展的新目标。在本篇综述中, 我们概...

Acute lung injury (ALI)is a common clinical disease that causes serious health problems worldwide, but the pathogenesis is still not clear. Autophagy is one of the current hot spots in biomedical research and involves a variety of pathophysiological processes. Recent studies have shown that autophagy is associated with the development of multiple lung diseases including ALI. Exosomes are nanoscale structures (30~100 nm)secreted by a variety of living cells and surrounded by lipid bilayer membranes. It regulates cell-cell communication and interactions by delivering proteins, lipids, and nuclei...