期刊论文

Effect of Compound Modified Sini Powder on Expression of Type Ⅰ and Type Ⅲ Collagen in Schistosoma Japonicum-infected Mice

中文

中国实验方剂学杂志

1005-9903

2010

16

16

178-181

10.3969/j.issn.1005-9903.2010.16.053

湖南省科技厅资助项目（04sk1007-26）；

本校为第一机构

目的：观察中药复方加味四逆散水煎剂对血吸虫病小鼠肝纤维化形成的影响。方法：NIH白鼠经皮肤人工感染日本血吸虫尾蚴造模,随机分为4组：B组（模型组）;C组（吡喹酮组）;D组（吡喹酮＋加味四逆散组）;E组（吡喹酮＋秋水仙碱组）,同时设A组（正常对照组）。病理证实小鼠肝组织纤维化形成后的第21 d开始给药治疗,第45 d时各治疗组分别予以吡喹酮300 mg·kg^-1一次性灌胃进行杀虫处理,第78 d处死小鼠,取肝组织切片HE染色观察病理变化,免疫组化法检测肝组织Ⅰ型、Ⅲ型胶原。结果：各组小鼠肝组织Ⅰ型胶原积分光密度均值比较：加味四逆散组明显低于模型组、吡喹酮组及秋水仙碱组（P〈0.05）。加味四...

Objective：To observe the effect of compound modified SiNi powder（JWSNS） on liver fibrosis in Schistosoma japonicum-infected Mice.Method： The NIH mice were successfully induced to liver fibrosis by infection with S.japonicum and then randomly divided into groups B,C,D and E.The mice in groups C,D and E were treated with praziquantel,praziquantel plus JWSNS and praziquantel plus colchicine,respectively.In addition,a group of unfected NIH mice（group A） served as normal control.Histological specimens were stained with HE.Expression of type Ⅰ...