Mefunidone ameliorates renal inflammation and tubulointerstitial fibrosis via suppression of IKKβ phosphorylation

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成果类型：

期刊论文

作者：

Zhang, Jin;Zheng, Linfeng;Yuan, Xiangning;Liu, Chunyan（刘春燕）;Yuan, Qiongjing;...

通讯作者：

Tao, Lijian

作者机构：

[Xie, Feifei; Zheng, Linfeng; Yuan, Xiangning; Yuan, Qiongjing; Peng, Zhangzhe; Tao, Lijian; Zhang, Jin] Cent S Univ, Xiangya Hosp, Dept Nephrol, Changsha 410008, Hunan, Peoples R China.

[Qiu, Sisi] Cent S Univ, Xiangya Hosp, Dept Gastroenterol, Changsha 410008, Hunan, Peoples R China.

[Liu, Chunyan] Hunan Univ Chinese Med, Dept Pathol, Changsha 410208, Hunan, Peoples R China.

[Tang, Yiting] Cent S Univ, Sch Basic Med Sci, Dept Physiol, Changsha 410013, Hunan, Peoples R China.

[Meng, Jie] Cent S Univ, Xiangya Hosp, Dept Respirat, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Tao, Lijian] C

Cent S Univ, Xiangya Hosp, Dept Nephrol Med, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

*IKKbeta/IkappaB;*Inflammatory response;*Macrophages;*NALP3;*Renal tubulointerstitial fibrosis

期刊：

The International Journal of Biochemistry & Cell Biology

ISSN：

1357-2725

年：

2016

卷：

页码：

109-118

DOI：

10.1016/j.biocel.2016.10.005

基金类别：

Doctoral Foundation of the Ministry of Education of ChinaMinistry of Education, China [20120162130001]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273575, 21172268, 81300610]; major new-drug developing fund of the National Science and Technology Foundation of China [2012ZX09103101]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Mefunidone is a new pyridone agent that attenuates renal tubulointerstitial fibrosis. However, the signaling pathways involved in the effect of mefunidone on renal tubulointerstitial fibrosis have not been well explained. Inflammatory response initiates and promotes renal tubulointerstitial fibrosis, and the inhibitor of nuclear factor kappa-B kinase beta (IKK beta) is a master regulator of inflammation. This study is determined to clarify the influence of mefunidone on renal inflammation and the phosphorylation of IKK beta. Experimental renal tubulointerstitial fibrosis was induced by unilate...

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Mefunidone ameliorates renal inflammation and tubulointerstitial fibrosis via suppression of IKKβ phosphorylation

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