期刊论文

Li, Ling;Tan, Y

英文

Molecules

1420-3049

2023

28

9

3775-

10.3390/molecules28093775

Conceptualization, Y.T., L.L. and X.Y.; methodology, S.X.; software, F.Z.; validation, S.H. and Z.Z.; formal analysis, X.S.; investigation, L.Z.; resources, S.X.; data curation, L.Z.; writing—original draft preparation, X.Y.; writing—review and editing, X.Y.; visualization, Z.Z.; supervision, F.Z.; project administration, X.S.; funding acquisition, Y.T. All authors have read and agreed to the published version of the manuscript. This study was supported by the Natural Science Foundation of Hunan Province (Grant No. 2022JJ40307) and the Scientific Research Projects of the Education Department of Hunan Province (Grant No. 20K093 and 21C0243).

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Protocatechuic acid (PCA) is a natural component with multiple biological activities. However, the underlying mechanisms of the effects of PCA on anti-ulcerative colitis (UC) are unclear. A UC mouse model was established by allowing the mice to freely drink a dextran sulfate sodium solution. The mice were administered PCA intragastrically for 7 days. Histological pathology, intestinal flora, and ferroptosis regulators were determined in vivo. Additionally, ferroptotic Caco-2 cells were modeled to investigate the role of PCA in ferroptosis. Our results showed that PCA reduced the levels of the ...