期刊论文

Tang, B.;Li, T.

英文

Biological & Pharmaceutical Bulletin

0918-6158

2022

45

9

1269-1275

10.1248/bpb.b22-00186

This study was supported by the Hunan Provincial Natural Science Foundation of China (Grant No. 2021JJ30505), the Scientific Research Fund of the Hunan Provincial Education Department (Grant Nos. 19B436 and 19C1409), the Hunan Administration of Traditional Chinese Medicine Science Foundation (Grant No. 2021215), the Scientific Research Foundation of Hunan University of Chinese Medicine (Grant No. 202024), the Excellent Teaching Team of Postgraduates in Hunan Province [Teaching Team of Postgraduates in Basic Medicine; Grant No. (2019)370-118]. The funding agencies had no role in the study design; collection, analysis, or interpretation of the data; writing of the report; or decision to submit the article for publication.

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Edaravone, an antioxidant protective agent, has anti-cerebral ischemic reperfusion injury (CIRI) effects, but its anti-CIRI mechanism is unclear. The aim of this study is to investigate the anti-CIRI mechanism of edaravone based on the nuclear factor-E2-related factor 2 (Nrf2)/ferroportin (FPN) pathway that regulates ferroptosis-mediated cerebral ischemia–reperfusion injury. We evaluated the brain injury by constructing a middle cerebral artery occlusion and reperfusion (MCAO/R) model in rats. The results showed that cerebral infarct volume an...