Hepatic transcriptome and proteome analyses provide new insights into the regulator mechanism of dietary avicularin in diabetic mice

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成果类型：

期刊论文

作者：

Zhu, Xiaoai;Qiu, Zhirou;Ouyang, Wen;Miao, Jianyin;Xiong, Ping;...

通讯作者：

Cao, Yong;Xiao, Hang

作者机构：

[Li, Minxiong; Cao, Yong; Miao, Jianyin; Xiong, Ping; Feng, Konglong; Luo, Minna; Zhu, Xiaoai] South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Nutraceut & Funct Food, Guangzhou 510642, Guangdong, Peoples R China.

[Xiao, Hang; Zhu, Xiaoai] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.

[Qiu, Zhirou] Zhaoqing Univ, Zhaoqing 526000, Peoples R China.

[Ouyang, Wen] Hunan Univ Chinese Med, Sch Pharm, Changsha 410007, Hunan, Peoples R China.

[Mao, Duobin] Zhengzhou Univ Light Ind, Sch Food & Biol Engn, Henan Key Lab Cold Chain Food Qual & Safety Contr, Collaborat Innovat Ctr Food Prod & Safety, Zhengzhou 450002, Henan, Peoples R China.

通讯机构：

[Cao, Yong] S

[Xiao, Hang] U

South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Nutraceut & Funct Food, Guangzhou 510642, Guangdong, Peoples R China.

Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.

语种：

英文

关键词：

Avicularin;Type 2 diabetes;Hypoglycemic;RNA-seq;iTRAQ;Molecular docking

期刊：

Food Research International

ISSN：

0963-9969

年：

2019

卷：

125

页码：

108570-

DOI：

10.1016/j.foodres.2019.108570

基金类别：

Department of Education of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2013gjhz0003]; Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods [20188030322010]; Guangdong Province Engineering Research Center for Bioactive Natural Products [2016B090920093]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31201321]; Education Department of Hunan Province [B13084]; China Scholarship CouncilChina Scholarship Council

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Many dietary flavonoids existing as glycosides in fruits and vegetables are considered bioactive food components with various potential health benefits. Type 2 diabetes mellitus (T2DM) is a complex and polygenic disease with increasing global prevalence and economic burden. In this study, the hypoglycemic effect of avicularin (quercetin-3-O-α-arabinofuranoside), a flavonoid glycoside commonly found in natural plants and fruits, was determined in a high fat diet/streptozotocin induced type 2 diabetes mouse model. Our results demonstrated that d...

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Hepatic transcriptome and proteome analyses provide new insights into the regulator mechanism of dietary avicularin in diabetic mice

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