Identifying Active Substances and the Pharmacological Mechanism of Houttuynia cordata Thunb. in Treating Radiation-Induced Lung Injury Based on Network Pharmacology and Molecular Docking Verification
Key Research and Development Projects in Hunan Province [2018SK2127]; First-Class Discipline Open Fund Project of Integrated Traditional Chinese of and Western Medicine of Hunan University of Chinese Medicine [2020ZXYJH44]
机构署名:
本校为第一且通讯机构
院系归属:
成人教育学院
研究生院
摘要:
Background. Houttuynia cordata Thunb. is a traditional Chinese herb widely used mainly because of the pharmacological effects related to heat clearance and detoxification. Emerging clinical evidence indicates that the efficacy of Houttuynia cordata Thunb. on RILI is upstanding. Nevertheless, its underlying therapeutic mechanism remains unclear and warrants further elucidation. Methods. The major active components and corresponding targets of Houttuynia cordata Thunb. were retrieved from the traditional Chinese medicine system pharmacology datab...