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Effects of QWBZP on T-cell subsets and their cytokines in intestinal mucosa of HRV infection suckling mice

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成果类型:
期刊论文
作者:
Wu, Can-rong*;Jiang, Xiao;He, Shuang-teng;Yang, Bo;Hu, Jian-zhong;...
通讯作者:
Wu, Can-rong
作者机构:
[Jiang, Xiao; Cai, Rui; Hu, Jian-zhong; Wu, Can-rong] Hunan Univ TCM, Dept Etiol & Immunol, Changsha 410007, Hunan, Peoples R China.
[Yang, Bo; He, Shuang-teng] Cent S Univ, Xiangya Hosp, Dept Integrat Med, Changsha 410008, Hunan, Peoples R China.
[Wu, Can-rong] Hunan Univ TCM, Dept Etiol & Immunol, Shaoshan Rd, Changsha 410007, Hunan, Peoples R China.
通讯机构:
[Wu, Can-rong] H
Hunan Univ TCM, Dept Etiol & Immunol, Shaoshan Rd, Changsha 410007, Hunan, Peoples R China.
语种:
英文
关键词:
Traditional Chinese Medicine;Qiwei Baizhu Powder;Human Rotavirus;Intestinal mucosa epithelial cells;Th1/Th2
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2010
卷:
131
期:
1
页码:
130-134
基金类别:
National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30772874]
机构署名:
本校为第一且通讯机构
摘要:
Aim of this study: Qiwei Baizhu Powder (QWBZP) is a traditional herbal prescription that has been used traditionally for the treatment of infantile diarrhea, including the infantile diarrhea caused by Human Rotavirus (HRV). In this study, we investigated the pharmacological activity of QWBZP extract. Materials and methods: NIH suckling mice with HRV induced diarrhea were used. Density of CD3(+), CD4(+) and CD8(+) T cells, mRNA expression of IL-2, IFN-gamma, IL-4 and IL-10 in intestinal mucosa epithelial cells were assayed. Results: QWBZP extract promoted the expressions of mRNA of IL-2, IL-4, ...

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