Bioconversion variation of ginsenoside CK mediated by human gut microbiota from healthy volunteers and colorectal cancer patients

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成果类型：

期刊论文

作者：

Guo, Yin-Ping;Shao, Li;Wang, Li;Chen, Man-Yun;Zhang, Wei;...

通讯作者：

Huang, WH

作者机构：

[Huang, Wei-Hua; Wang, Li; Huang, WH; Zhang, Wei; Guo, Yin-Ping; Chen, Man-Yun] Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Peoples R China.

[Shao, Li] Hunan Univ Chinese Med, Sch Pharm, Dept Pharmacognosy, Changsha 410128, Hunan, Peoples R China.

[Huang, Wei-Hua; Wang, Li; Zhang, Wei; Guo, Yin-Ping; Chen, Man-Yun] Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Peoples R China.

[Huang, Wei-Hua; Wang, Li; Zhang, Wei; Guo, Yin-Ping; Chen, Man-Yun] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Xiangya Rd 110, Changsha 410008, Peoples R China.

[Huang, Wei-Hua] Hunan Prov Maternal & Child Hlth Care Hosp, NHC Key Lab Birth Defect Res & Prevent, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Huang, WH ] C

Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Peoples R China.

语种：

英文

关键词：

Ginsenoside CK;Gut microbiota;LC-MS/MS;Colorectal cancer;16S rRNA gene sequencing

期刊：

Chinese Medicine

ISSN：

1749-8546

年：

2021

卷：

期：

页码：

1-10

DOI：

10.1186/s13020-021-00436-z

基金类别：

This work was supported by the National Natural Scientific Foundation of China (82074000, 81903784), the Hunan Provincial Natural Science Foundation of China (2020JJ4878), the Scientific Research Project of Department of Education of Hunan Province (20K136), and NHC Key Laboratory of Birth Defect for Research and Prevention (Hunan Provincial Maternal and Child Health Care Hospital, No. KF2020002).

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本校为其他机构

院系归属：

药学院

摘要：

AbstractBackgroundGinsenoside CK (GCK) serves as the potential anti-colorectal cancer (CRC) protopanaxadiol (PPD)-type saponin, which could be mainly bio-converted to yield PPD by gut microbiota. Meanwhile, the anti-CRC effects of GCK could be altered by gut microbiota due to their different diversity in CRC patients. We aimed to investigate the bioconversion variation of GCK mediated by gut microbiota from CRC patients by comparing with healthy subjects.MethodsGut microbiota profiled by 16S rRNA gene sequencing were collected from healthy volu...

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Bioconversion variation of ginsenoside CK mediated by human gut microbiota from healthy volunteers and colorectal cancer patients

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