期刊论文

Zhou Xiaoqing

中文

数字中医药(英文)

2096-479X

2021

4

01

54-63

10.1016/j.dcmed.2021.03.007

funding support from the University Research Funding Project of the Hunan Provincial Department of Education （No. 15C1406）；

本校为第一且通讯机构

目的探讨三七总皂苷和丹参酮ⅡA对炎症相关性结直肠癌小鼠的预防作用及可能的作用机制。方法将88只C57BL/6雄性小鼠,按随机数字表法分为11组,每组8只;分别为氧化偶氮甲烷+葡聚糖硫酸钠（AOM+DSS）模型对照组,三七总皂苷低、中、高剂量组,丹参酮ⅡA低、中、高剂量组,三七总皂苷+丹参酮ⅡA低、中、高剂量组,空白组;前10组腹腔注射AOM诱导炎症相关结直肠癌,空白组腹腔注射等量0.9%Nacl溶液;前10组第5天开始连续自由饮用2.5%DSS水溶液,五天为一周期,每三周一个周期,共三个周期,空白对照组正常饮水。第3周开始药物组每天分别给予三七总皂苷低、中、高剂量,丹参酮ⅡA低、中、高剂量,三七总皂苷+丹参酮...

Objective: To explore the preventive effects and possible me-chanisms of action of notoginsenoside (NGS) and tanshinone IIA (TSN) in inflammation-related colorectal cancer (IRCC) in mice. Methods: Eighty-eight male C57BL/6 mice were randomly assigned to 11 groups (n = 8 each group). Azomethane oxide + dextran sulfate (AOM + DSS) model control (model), NGS low-dose (l-NGS), NGS medium-dose (m-NGS), NGS high-dose (h-NGS), TSN low-dose (l-TSN), TSN medium-dose (m-TSN), TSN high-dose (h-TSN), (NGS + TSN) low-dose [l-(NGS + TSN)], (NGS + TSN) medium...