期刊论文

Effect and Mechanism of Baicalin and Baicalein Induced Cell Apoptosis in Breast Cancer Cells

中文

湖南中医药大学学报

1674-070X

2014

5

23-27

10.3969/j.issn.1674-070X.2014.05.006.023.05

高等学校博士学科点专项科研基金资助课题（20114323110006）； 湖南省高校创新平台开放基金（湘财教指[2009]70号-09k058）；

本校为第一机构

目的：探讨黄芩苷和黄芩素联合应用对乳腺癌细胞凋亡的诱导作用及其相关机制。方法将不同浓度的黄芩苷、黄芩素以及两者联合作用于人乳腺癌(Michigan Cancer Foundation 7，MCF-7)细胞。检测上述化合物对乳腺癌细胞的活力、凋亡情况以及凋亡相关蛋白表达的影响。结果黄芩苷或黄芩素作用于乳腺癌细胞后，与作用前相比细胞生长抑制率显著升高(P

Objective To study the breast cancer cell apoptosis is induced by the com bination therapy of baicalin and baicalein and its related m echanism .Methods Different concentrations of baicalin, baicalein and com bined effects of the two drugs in breast cancer MCF-7 cells, test-ing drugs on breast cancer cell viability, apoptosis and apoptosis-related protein expression.Results Baicalin or baicalein acting on the breast cancer cells, cell grow th inhibition was significant-ly higher（P〈0.05）;com pared with baicalin or baicalein alone, the combina...