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Memory enhancement of fresh ginseng on deficits induced by chronic restraint stress in mice.

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成果类型:
期刊论文
作者:
Dong, Liming;Wang, Yi;Lv, Jingwei;Zhang, Hongxia;Jiang, Ning;...
通讯作者:
Liu, XM
作者机构:
[Wang, Yi; Lv, Jingwei; Lu, Cong; Jiang, Ning; Xu, Pan; Dong, Liming; Liu, Xinmin] Chinese Acad Med Sci, Res Ctr Pharmacol & Toxicol, Inst Med Plant Dev IMPLAD, Beijing, Peoples R China.
[Wang, Yi; Lv, Jingwei; Liu, Xinmin; Lu, Cong; Jiang, Ning; Xu, Pan; Dong, Liming] Peking Union Med Coll, Beijing, Peoples R China.
[Zhang, Hongxia] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.
[Liu, Xinmin] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing, Peoples R China.
通讯机构:
[Liu, XM ] P
Peking Union Med Coll, Beijing, Peoples R China.
Chinese Acad Med Sci, Inst Med Plant Dev, Beijing, Peoples R China.
语种:
英文
关键词:
donepezil;ginseng extract;malonaldehyde;antioxidant;adult;animal behavior;animal experiment;animal model;antioxidant activity;Article;chronic stress;cognition;cognitive defect;controlled study;dementia;discrimination index;escape latency;experimental behavioral test;ginseng;learning and memory test;male;memory;memory disorder;Morris water maze test;mouse;neuroprotection;nonhuman;novel object recognition test;object location recognition test;oxidative stress;priority journal;spatial learning;spatial memory;animal;drug effect;exercise;Institute for Cancer Research mouse;mental stress;metabolism;Panax;prevention and control;recognition;Animals;Antioxidants;Male;Mice, Inbred ICR;Oxidative Stress;Panax;Recognition (Psychology);Restraint, Physical;Spatial Learning;Spatial Memory;Stress, Psychological
期刊:
Nutritional Neuroscience
ISSN:
1028-415X
年:
2019
卷:
22
期:
4
页码:
235-242
基金类别:
Funding This work was supported by Chinese Academy of Medical Sciences and Peking Union Medical College [2016-I2M-2-006], Ministry of Science and Technology of the People’s Republic of China [2011DFA32730], Ministry of Science and Technology of the People’s Republic of China [2017ZX09301-029] and National Natural Science Foundation of China [81773930].
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Objectives: Chronic stress exposure can disrupt the balance of organisms, result in learning and memory impairments and induce oxidative stress. However, there is a lack of safe and effective long-term therapeutic agents for stress-related injuries. Fresh ginseng (FG), an unprocessed raw root of ginseng, has antioxidant and neuroprotective activities and has been used as functional health food in Asian countries for many years. The aim of this study was to verify the protective effects of FG on chronic restraint stress (CRS)-induced learning and memory impairments as well as oxidative stress d...

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