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Risk factors and drug discovery for cognitive impairment in type 2 diabetes mellitus using artificial intelligence interpretation and graph neural networks

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成果类型:
期刊论文
作者:
Zhang, Xin;Xie, Jiajia;You, Xiong;Gong, Houwu
通讯作者:
Gong, HW
作者机构:
[Zhang, Xin] Hunan Coll Tradit Chinese Med, Affiliated Hosp 1, Dept Pediat, Zhuzhou, Peoples R China.
[Xie, Jiajia] Hunan Univ Chinese Med, Hosp 1, Dept Ultrasound Imaging, Changsha, Peoples R China.
[You, Xiong] Hunan Prov Rehabil Hosp, Ctr Rehabil Diag & Treatment, Changsha, Peoples R China.
[Gong, Houwu] Hunan Univ, Coll Comp Sci & Elect Engn, Changsha, Peoples R China.
[Gong, Houwu] Acad Mil Sci, Mil Med Res Inst, Beijing, Peoples R China.
通讯机构:
[Gong, HW ] H
Hunan Univ, Coll Comp Sci & Elect Engn, Changsha, Peoples R China.
Acad Mil Sci, Mil Med Res Inst, Beijing, Peoples R China.
语种:
英文
关键词:
type 2 diabetes mellitus;cognitive impairment;Risk factors;Drug Discovery;graph neural network (GNN)
期刊:
Frontiers in Endocrinology
ISSN:
1664-2392
年:
2023
卷:
14
基金类别:
Natural Sciences Foundation of Hunan Province [2021JJ30139]; National Natural Science Foundation of China [61773157]; China Postdoctoral Science Foundation [2022M711113]; 2021 Scientific Research Plan Project of Hunan Provincial Health Commission [202109021496]; Rehabilitation Project of Hunan Disabled Persons' Federation [2022XK0305]
机构署名:
本校为第一机构
院系归属:
第一中医临床学院
摘要:
Background: Among the 382 million diabetic patients worldwide, approximately 30% experience neuropathy, and one-fifth of these patients eventually develop diabetes cognitive impairment (CI). However, the mechanism underlying diabetes CI remains unknown, and early diagnostic methods or effective treatments are currently not available.Objective: This study aimed to explore the risk factors for CI in patients with type 2 diabetes mellitus (T2DM), screen potential therapeutic drugs for T2DM-CI, and provide evidence for preventing and treating T2DM-CI.Methods: This study focused on the T2DM populat...

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