期刊论文

Protective effects of total polyphenols from Acanthopanx trifoliatus(L.)Merr.on Aβ25-35-induced oxidative damage and AAPH-induced aging models in PC12 cells

中文

浙江理工大学学报(自然科学版)

1673-3851

2023

49

3

353-358

10.3969/j.issn.1673-3851(n).2023.03.008

浙江省基础公益研究计划项目(LGN22H280004)。

本校为其他机构

为探究中药白簕(Acanthopanx trifoliatus(L.) Merr.)能否作为高效、低毒的防治阿尔茨海默病的天然药物原料,选用大鼠肾上腺嗜铬细胞瘤株PC12作为神经细胞模型,建立Aβ25-35展开更多 为探究中药白簕(Acanthopanx trifoliatus(L.) Merr.)能否作为高效、低毒的防治阿尔茨海默病的天然药物原料,选用大鼠肾上腺嗜铬细胞瘤株PC12作为神经细胞模型,建立Aβ25-35诱导的PC12细胞氧化损伤模型,测定白簕叶总多酚干预24 h后PC12细胞存活率;通过AAPH诱导的PC12细胞衰老模型和β-半乳糖苷酶活性染色法评估PC12细胞衰老情况。结果表明:与仅损伤处理组相比,5~60 mg/L的白簕叶总多酚能够显著提高(p

In order to explore the possibility of Acanthopanx trifoliatus(L.)Merr.as a highly effective and low toxic agent for the prevention and treatment of Alzheimer's disease,PC12,a rat adrenal pheochromocytoma cell line,was selected as the nerve cell model,the oxidative ...MORE In order to explore the possibility of Acanthopanx trifoliatus(L.)Merr.as a highly effective and low toxic agent for the prevention and treatment of Alzheimer's disease,PC12,a rat adrenal pheochromocytoma cell line,was selected as the nerve cell model,the oxidative damage mod...