Pathogenesis of acquired heterotopic ossification: Risk factors, cellular mechanisms, and therapeutic implications

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cao, Guorui;Zhang, Shaoyun;Wang, Yixuan;Quan, Songtao;Yue, Chen;...

通讯作者：

Tan, H.

作者机构：

[Yao, Junna; Tan, Honglue; Cao, Guorui; Quan, Songtao; Yue, Chen] Luoyang Orthoped Hosp Henan Prov, Orthoped Hosp Henan Prov, Dept Knee Surg, 82 Qiming South Rd, Luoyang 471000, Henan, Peoples R China.

[Zhang, Shaoyun] Third Hosp Mianyang, Sichuan Mental Hlth Ctr, Dept Orthoped, Mianyang, Sichuan, Peoples R China.

[Wang, Yixuan] Hunan Univ Chinese Med, Changsha, Hunan, Peoples R China.

[Alexander, Peter G.] Univ Pittsburgh, Ctr Cellular & Mol Engn, Dept Orthopaed Surg, Sch Med, Pittsburgh, PA USA.

通讯机构：

[Tan, H.] D

Department of Knee Surgery, 82 Qiming South Road, Henan Province, China

语种：

英文

关键词：

Heterotopic ossification;Macrophage;Risk factors;Stem cells;Treatment

期刊：

Bone

ISSN：

8756-3282

年：

2023

卷：

168

页码：

116655

DOI：

10.1016/j.bone.2022.116655

基金类别：

This research was supported by funding from the National Natural Science Foundation of China ( 82104896 ).

机构署名：

本校为其他机构

摘要：

Heterotopic ossification (HO), including hereditary and acquired HO, is the formation of extraskeletal bone in skeletal muscle and surrounding soft tissues. Acquired HO is often caused by range of motion, explosion injury, nerve injury or burns. Severe HO can lead to pain and limited joint activity, affecting functional rehabilitation and quality of life. Increasing evidence shows that inflammatory processes and mesenchymal stem cells (MSCs) can drive HO. However, explicit knowledge about the specific mechanisms that result in HO and related cell precursors is still limited. Moreover, there ar...

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Pathogenesis of acquired heterotopic ossification: Risk factors, cellular mechanisms, and therapeutic implications

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