期刊论文

Characteristics of UPLC fingerprints and division of"imprinting templates"component clusters of 13 Chinese materia medicas returning to lung meridian

中文

湖南中医药大学学报

1674-070X

2022

42

10

1669-1676

10.3969/j.issn.1674-070X.2022.10.013

81573691:国家自然科学基金 81874507:国家自然科学基金 S202010541043:湖南省大学生创新创业训练计划项目

本校为第一机构

目的 对13味归肺经中药的UPLC指纹图谱特征进行研究,探究其"印迹模板"成分簇特征和划归方法,为寻找中药归经的物质基础研究方法提供参考.方法 采用UPLC建立白前、百部、苍耳子、芥子、金荞麦、桔梗、款冬花、马勃、前胡、桑白皮、射干、鱼腥草、紫菀13味归肺经中药的指纹图谱,并用总量统计矩、信息熵与信息量进行特征分析;采用匹配频数法划分"印迹模板"成分簇,寻找可能的归肺经的物质基础.结果 13味归肺经中药的UPLC指纹图谱平均色谱峰峰数为80个,RSD为33.18％;总量统计零阶矩、一阶矩、二阶矩、相似度、信息熵、信息量分别为19230μA·s、27.21 min、435.0 min2、0.5517、4.260 bit、70234 bit...

Objective To study the characteristics of UPLC fingerprints of 13 Chinese materia medicas(CMMs)returning to lung meridian,and to explore the characteristics and classification method of"imprinting templates"component cluster,so as to provide reference for methodology research on material bases of meridian tropism of TCM.Methods UPLC was used to establish the fingerprints of 13 CMMs:Baiqian(Cynanchi Stauntonii Rhizoma Et Radix),Baibu(Stemonae Radix),Cang’erzi(Xanthii Fructus),Jiezi(Sinapis Semen),Jinqiaomai(Fagopyri Dibotryis Rhizoma),Jiegeng(P...