Spatial amine metabolomics and histopathology reveal localized brain alterations in subacute traumatic brain injury and the underlying mechanism of herbal treatment

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成果类型：

期刊论文

作者：

Hu, En;Tang, Tao;Li, You-mei;Li, Teng;Zhu, Lin;...

作者机构：

[Wang, Yang; Zhu, Lin; Wu, Yao; Hu, En; Tang, Tao; Ding, Ruo-qi; Li, Teng] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China.

[Wang, Yang; Huang, Qing; Zhu, Lin; Wu, Yao; Hu, En; Tang, Tao; Ding, Ruo-qi; Li, Teng] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.

[Li, You-mei; Wu, Qian] Cent South Univ, Coll Chem & Chem Engn, Changsha, Hunan, Peoples R China.

[Huang, Qing] Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha, Hunan, Peoples R China.

[Zhang, Wei] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Xuefu Zhuyu decoction;amine metabolites;angiogenesis;spatial metabolomics;traumatic brain injury

期刊：

CNS Neuroscience & Therapeutics

ISSN：

1755-5930

年：

2023

DOI：

10.1111/cns.14231

基金类别：

National Natural Science Foundation of China [81874425, 81973665, 82174259, 22074159, 21804142]; Hunan Scientific Research Program of TCM [2021032, D2022065]; National Science Foundation of Hunan Province [2022JJ40853]; Fundamental Research Funds for the Central Universities of Central South University [2021zzts0351]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

The study uses an LMJSS‐TMT‐UPLC‐MS method to spatially map amine metabolites to brain histopathological changes including neuron loss, glial cell activation, and neurogenesis. This integrated study explains the mechanisms of posttraumatic brain injury brain damage and repair. It also uncovers the therapeutic mechanisms of traditional Chinese medicine, Xuefu Zhuyu decoction. Abstract Introduction Spatial changes of amine metabolites and histopathology of the whole brain help to reveal the mechanism of traumatic brain injury (TBI) and treatme...

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Spatial amine metabolomics and histopathology reveal localized brain alterations in subacute traumatic brain injury and the underlying mechanism of herbal treatment

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