An exploration of the effect of Chinese herbal compound on the occurrence and development of large intestine cancer and intestinal flora

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成果类型：

期刊论文

作者：

Liu, Pingyu;Ying, Jian;Guo, Xin;Tang, Xiaohui;Zou, Wenjuan;...

通讯作者：

Song, Na;Cheng, J

作者机构：

[Guo, Xin; Xu, Xinyi; Liu, Pingyu] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Tang, Xiaohui; Ying, Jian; Song, Na; Zou, Wenjuan; Zhao, Bin; Cheng, Jun] Chongqing Hosp Tradit Chinese Med, Dept Oncol, Chongqing 400021, Peoples R China.

[Wang, Tiantian] Chongqing Hosp Tradit Chinese Med, Dept Emergency Intens Care, Chongqing 400021, Peoples R China.

[Song, Na; Song, N; Cheng, Jun] Chongqing Hosp Tradit Chinese Med, Dept Oncol, 6 Panxi Qi Zhi Rd, Chongqing 400021, Peoples R China.

通讯机构：

[Song, N; Cheng, J ] C

Chongqing Hosp Tradit Chinese Med, Dept Oncol, 6 Panxi Qi Zhi Rd, Chongqing 400021, Peoples R China.

语种：

英文

关键词：

Chinese herbal compound;Large intestine cancer;AOM/DSS-Induced colorectal cancer mice;16S rRNA;Inflammation

期刊：

Heliyon

ISSN：

2405-8440

年：

2024

卷：

期：

页码：

e23533

DOI：

10.1016/j.heliyon.2023.e23533

基金类别：

Project of Chongqing Science and Technology Bureau, China [cstc2019jxj1130013]; Chongqing Science and Health Joint Medical Research Project [2022ZDXM036]; Special Project for Performance Incentive and Guidance of Scientific Research Institutions in Chongqing [cstc2021jxjl130020]

机构署名：

本校为第一机构

摘要：

This study was conducted to observe the effect of Chinese herbal compound on the treatment of colon cancer using AOM/DSS-induced C57BL/6J colon cancer mice and to validate potential influence on intestinal flora of mice. A colorectal cancer (CRC) mouse model was built with a total of 50 C57BL/6J mice that were induced by administrating AOM/DSS. These experimental animals were split up into 5 groups, a control group, a model group, and low-, medium- and high-dose Chinese herbal compound groups. All mice were given Chinese herbal compound treatme...

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An exploration of the effect of Chinese herbal compound on the occurrence and development of large intestine cancer and intestinal flora

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