期刊论文

Wang Xianchun<&wdkj&>Zeng Xiongzhi

英文

Channels

1933-6950

2022

16

1

72-83

10.1080/19336950.2022.2053420

This work was supported by the National Natural Science Foundation of China (82104324, 31271135, 31070700), Scientific Research Project of Hunan Provincial Department of Education (19C1407), Scientific Research Foundation of Hunan University of Traditional Chinese Medicine (2020XJJJ030), The key discipline of biological engineering of Hunan University of Chinses medicine ([2018] No.3), and Scientific Research Foundation of Hunan Key Laboratory of Chinese Materia Medica Powder and Innovative Drugs Established by Provincial and Ministry ([2020] No.1).

本校为第一机构

JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4.3 expressed in Xenopus oocytes but had no effects on Kv1.2-1.4. However, the underlying action mechanism of JZTX-V on Kv4.3 remains unclear. In our study, JZTX-V could inhibit not only transient outward potassium currents evoked in small-sized DRG neurons but also Kv4.3-encoded currents expressed in HEK293T cells in the concentration and voltage depen...