期刊论文

Yue, SJ

英文

EXPERIMENTAL AND THERAPEUTIC MEDICINE

1792-0981

2014

8

3

747-753

10.3892/etm.2014.1796

National Natural Science Foundation of China [81070522, 81000264, 81370098]; Open Fund Project of the University Innovation Platform of Hunan Province [2010.1-2012.12]

本校为其他机构

Hypoxia is necessary for fetal development; however, excess hypoxia is detrimental. The mechanisms underlying the effects of hypoxia on lung development remain unclear, although important roles of microRNAs (miRNAs) during lung development have recently been established. However, the effect on lung development at an miRNA expression level, following changes in oxygen tension, have not yet been studied. In the present study, pregnant rats were exposed to a fraction of inspired oxygen of 10.5 or 21% for two days on gestation day 19, following which the body weight, lung wet weight, radial alveol...