Integrating LC-MS profiling, network pharmacology and computational modeling to decipher the multi-target mechanism of Banxia Houpu Decoction against liver cancer

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成果类型：

期刊论文

作者：

Si Yan;Guang-Shuai Zhang;Yan Liu;Zi-Wei Du;Qing Min;...

作者机构：

[Si Yan; Guang-Shuai Zhang; Yan Liu; Zi-Wei Du; Qing Min] School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.

Research Center for Precision Medication of Chinese Medicine, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.

Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China.

[Xiao-He Xiao] Research Center for Precision Medication of Chinese Medicine, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.<&wdkj&>Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China.

[Shuang-Lin Qin] School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.<&wdkj&>Research Center for Precision Medication of Chinese Medicine, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.<&wdkj&>Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China.

通讯机构：

[Xiao-He Xiao] R

[Shuang-Lin Qin] S

语种：

英文

关键词：

Banxia Houpu Decoction;liquid chromatography-mass spectrometry;liver cancer;network pharmacology;molecular docking

期刊：

Cancer Advances

年：

2025

卷：

页码：

e25001-e25030

DOI：

10.53388/2025825007

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Background: Liver cancer (LC) remains a leading cause of cancer-related mortality worldwide, with current treatments often limited by suboptimal efficacy and adverse effects. Banxia Houpu Decoction (BHD), a traditional Chinese herbal formula, has demonstrated potential anti-tumor properties in clinical practice. However, its precise mechanisms against LC remain unclear. This study employs network pharmacology (NP) and molecular docking (MD) approaches to systematically identify BHD’s active components and their molecular targets, aiming to elu...

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Integrating LC-MS profiling, network pharmacology and computational modeling to decipher the multi-target mechanism of Banxia Houpu Decoction against liver cancer

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