Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1/ERK/HIF-1α pathway through in silico analysis and experimental validation

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成果类型：

期刊论文

作者：

Yang, Tong;Liu, Xiaolu;Zhou, Yue;Du, Lipeng;Fu, Yang;...

通讯作者：

Feng, Zhitao;Ge, Jinwen;Mei, Zhigang

作者机构：

[Yang, Tong; Mei, Zhigang; Zhou, Yue] Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China

[Du, Lipeng; Liu, Xiaolu; Luo, Yanan] Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, College of Medicine and Health Sciences, China Three Gorges University, Yichang, 443002, Hubei, China

[Liu, Xiaolu] State Key Laboratory of Natural Medicines and School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China

[Fu, Yang] Xiangyang Hospital of Traditional Chinese Medicine, Xiangyang, 441000, Hubei, China

[Zhang, Wenli] School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China

通讯机构：

[Mei, Zhigang; Feng, Zhitao] T

[Ge, Jinwen] K

Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, College of Medicine and Health Sciences, China Three Gorges University, Yichang, 443002, Hubei, China. Electronic address:

Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China. Electronic address:

语种：

英文

关键词：

Apoptosis;Cerebral ischemia-reperfusion injury;HIF-1 signaling pathway;MAPK signaling pathway;Network pharmacology;Sanpian decoction

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2023

卷：

318

期：

Pt A

页码：

116898

DOI：

10.1016/j.jep.2023.116898

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

药学院

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: Cerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process involving multiple factors, and becomes the footstone of rehabilitation after ischemic stroke. Sanpian decoction (SPD) has exhibited protective effects against CIRI, migraine, and other cerebral vascular diseases. However, the underlying mechanisms have not been completely elucidated. AIM OF THE STUDY: This study sought to explore the potential mechanisms underlying the effect of SPD against CIRI. MATERIALS AND METHODS: High-perfo...

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Sanpian decoction ameliorates cerebral ischemia-reperfusion injury by regulating SIRT1/ERK/HIF-1α pathway through in silico analysis and experimental validation

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