Protective effects of Radix Stellariae extract against Alzheimer\'s disease via autophagy activation in Caenorhabditis elegans and cellular models - 成果

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Protective effects of Radix Stellariae extract against Alzheimer's disease via autophagy activation in Caenorhabditis elegans and cellular models

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成果类型：

期刊论文

作者：

Long, Tao;Chen, Xue;Zhang, Yue;Zhou, Yu-Jia;He, Yan-Ni;...

通讯作者：

Qin, Da-Lian;Wu, An-Guo;Zhou, XG

作者机构：

[Wu, Jian-Ming; Fu, Hai-Jun; Zhou, Xiao-Gang; Long, Tao; Chen, Xue; Yu, Chong-Lin; Zhang, Yue; Qin, Da-Lian; Wu, An-Guo; Zhou, XG; He, Yan-Ni; Qin, DL; Yu, Lu; Zhu, Yun-Fei] Southwest Med Univ, Sch Pharm, Luzhou Key Lab Act Screening & Druggabil Evaluat C, Key Lab Med Electrophysiol,Minist Educ, Luzhou 646000, Sichuan, Peoples R China.

[Fu, Hai-Jun; Zhou, Xiao-Gang; Long, Tao; He, Yan-Ni; Zhu, Yun-Fei] Cent Nervous Syst Drug Key Lab Sichuan Prov, Luzhou 646000, Sichuan, Peoples R China.

[Zhou, Yu-Jia] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.

[Law, Betty Yuen-Kwan] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China.

通讯机构：

[Wu, AG; Zhou, XG ; Qin, DL] S

Southwest Med Univ, Sch Pharm, Luzhou Key Lab Act Screening & Druggabil Evaluat C, Key Lab Med Electrophysiol,Minist Educ, Luzhou 646000, Sichuan, Peoples R China.

语种：

英文

关键词：

Alzheimer’s disease;Autophagy;C. elegans;PC-12 cells;Radix Stellariae

期刊：

Biomedicine & Pharmacotherapy

ISSN：

0753-3322

年：

2023

卷：

165

页码：

115261

DOI：

10.1016/j.biopha.2023.115261

基金类别：

Science and Technology Planning Project of Sichuan Province, China [2021YJ0180, 2020YJ0494, 2022YFS0620]; Joint project of Luzhou Municipal People's Government and Southwest Medical University, China [20YKDYYJC0067, 2020LZXNYDJ37]; Joint project of First People's Hospital of Neijiang and Southwest Medical University, China [2021NJXNYD04]; project of Southwest Medical University, China [2020ZRZD015, 2021ZKZD015, 2021ZKZD018, 2021ZKMS046, 2019ZQN174]; Macao Science and Technology Development Fund, Macau Special Administrative Region [MUST-SKL-2021-005]

机构署名：

本校为其他机构

院系归属：

中西医结合学院

摘要：

Enhancing the clearance of proteins associated with Alzheimer's disease (AD) emerges as a promising approach for AD therapeutics. This study explores the potential of Radix Stellariae, a traditional Chinese medicine, in treating AD. Utilizing transgenic C. elegans models of AD, we demonstrated that a 75% ethanol extract of Radix Stellariae (RSE) (at 50µg/mL) effectively diminishes Aβ and Tau protein expression, and alleviates their induced impairments including paralysis, behavioral dysfunction, neurotoxicity, and ROS accumulation. Additional...

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Protective effects of Radix Stellariae extract against Alzheimer's disease via autophagy activation in Caenorhabditis elegans and cellular models

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