期刊论文

中文

中国实验方剂学杂志

1005-9903

2006

12

9

28-31

10.3969/j.issn.1005-9903.2006.09.014

湖南省自然科学基金资助项目（03JJY3041）；

本校为第一机构

目的：观察月华胶囊对耐多药结核鼠T淋巴细胞亚群、TH１／TH2细胞因子的影响及其机理。方法：将耐多药结核鼠随机分成模型组、月华胶囊组、抗结核药（OEZD）组、月华胶囊＋抗结核药组，另设正常组。测各组中的CD4、CD8、CD4／CD8、IFN-γ、IL-2、IL-10、TNF-α。结果：①与模型组比较，月华胶囊组、抗结核药组、月华胶囊＋抗结核药组均明显减少CD4、CD4／CD8、INF－γ、IL-2降低（P〈0．01），明显改善IL-10、INF-α升高（P〈0．05）；②与抗结核药组比较，月华胶囊＋抗结核药组各指标差异均有显著性（P〈0、05）。结论：月华胶囊对耐多药结核鼠有治疗作用，其机理是通过调控T淋巴细胞亚群CD4、...

Objective：To observe the possible influence of YUEHUA capsule（YHC） on T Lymphocyte subgroup and TH1/TH2 cytokines in rats with Multi-drug resistant tuberculosis （MDR-TB） and its mechanism for this effeci. Methods：The experimental rats,as the studying model, were Divided into the modeling group, YHC group, the drug of antituberculosis （OEZD） group and YHC ＆ OEZD group in random process. And there was normal group. Then CD4^＋ , CD8^＋ , CD4 ^＋/CD8^＋ , IFN-γ, IL-2, IL-10, and TNF-α were observed in the all group. Result：Compared wit...