The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia

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成果类型：

期刊论文

作者：

Tan, Yong;Liu, Xinru;Zhou, Ke;He, Xiaojuan;Lu, Cheng;...

通讯作者：

Lu, Aiping;Zhang, Weidong;Zhang, Ge

作者机构：

[He, Xiaojuan; Lu, Aiping; Niu, Xuyan; Tan, Yong; Lu, Cheng] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing, Peoples R China.

[Liu, Xinru; Zhang, Weidong; Zu, Xianpeng] Second Mil Med Univ, Sch Pharm, Shanghai, Peoples R China.

[Zhou, Ke] Hunan Univ Chinese Med, Affiliated Hosp 2, Changsha, Hunan, Peoples R China.

[Lu, Aiping; Zhang, Weidong; Lu, AP; Zhang, Ge; He, Bing; Bian, Zhaoxiang; Xu, Gang] Hong Kong Baptist Univ, Sch Chinese Med, Inst Adv Translat Med Bone & Joint Dis, Hong Kong, Hong Kong, Peoples R China.

[Xiao, Cheng] China Japan Friendship Hosp, Beijing, Peoples R China.

通讯机构：

[Lu, Aiping] C

[Zhang, Weidong; Lu, Aiping] S

[Zhang, G; Lu, AP] H

China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing, Peoples R China.

Second Mil Med Univ, Sch Pharm, Shanghai, Peoples R China.

语种：

英文

关键词：

Metabolic pathways;Purine metabolism;Metabolites;Metabolic networks;Enzyme metabolism;Inosine;Phospholipases;Uric acid

期刊：

PLoS ONE

ISSN：

1932-6203

年：

2016

卷：

期：

页码：

e0149043-

DOI：

10.1371/journal.pone.0149043

基金类别：

National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81230090]; Hong Kong Baptist University Strategic Development Fund [SDF13-1209-P01]; Interdisciplinary Research Matching Scheme of Hong Kong Baptist University [RC-IRMS/12-13/02]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2013M541158]; E-Institutes of the Shanghai Municipal Education Commission [E03008]; Professor of Chang Jiang Scholars Program

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

摘要：

Hyperuricemia (HU) often progresses to combine with non-alcoholic fatty liver disease (NAFLD) in the clinical scenario, which further exacerbates metabolic disorders; early detection of biomarkers, if obtained during the HU progression, may be beneficial for preventing its combination with NAFLD. This study aimed to decipher the biomarkers and mechanisms of the development of steatosis in HU. Four groups of subjects undergoing health screening, including healthy subjects, subjects with HU, subjects with HU combined with NAFLD (HU+NAFLD) and subjects with HU initially and then with HU+NAFLD one...

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The Potential Biomarkers to Identify the Development of Steatosis in Hyperuricemia

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