Mefunidone Attenuates Tubulointerstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction

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成果类型：

期刊论文

作者：

Liu, Chunyan（刘春燕）;Mei, Wenjuan;Tang, Juan;Yuan, Qiongjing;Huang, Ling;...

通讯作者：

Tao, Lijian

作者机构：

[Liu, Chunyan; Huang, Ling; Yuan, Qiongjing; Peng, Zhangzhe; Tao, Lijian; Tang, Juan; Mei, Wenjuan; Lu, Miaomiao; Wu, Lin] Cent S Univ, Xiangya Hosp, Dept Nephrol, Changsha, Hunan, Peoples R China.

[Liu, Chunyan] Hunan Univ Chinese Med, Dept Pathol, Changsha, Hunan, Peoples R China.

[Meng, Jie] Cent S Univ, Xiangya Hosp, Dept Respirat, Changsha, Hunan, Peoples R China.

[Yang, Huixiang] Cent S Univ, Xiangya Hosp, Dept Gastroenterol, Changsha, Hunan, Peoples R China.

[Shen, Hong] Cent S Univ, Xiangya Hosp, Inst Med Sci, Changsha, Hunan, Peoples R China.

通讯机构：

[Tao, Lijian] C

Cent S Univ, Xiangya Hosp, Dept Nephrol, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Kidneys;Collagens;Fibrosis;Macrophages;Inflammation;Transcription factors;Fibroblasts;Phosphorylation

期刊：

PLoS ONE

ISSN：

1932-6203

年：

2015

卷：

期：

页码：

e0129283-

DOI：

10.1371/journal.pone.0129283

基金类别：

Doctoral Foundation of the Ministry of Education of ChinaMinistry of Education, China [20120162130001]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273575, 21172268, 81300610]; major new-drug developing fund of National Science and Technology Foundation of China [2012ZX09103101]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

BACKGROUND: Inflammation has a crucial role in renal interstitial fibrosis, which is the common pathway of chronic kidney diseases. Mefunidone (MFD) is a new compound which could effectively inhibit the proliferation of renal fibroblasts in vitro. However, the overall effect of Mefunidone in renal fibrosis remains unknown. METHODS: Sprague-Dawley rats were randomly divided intro 6 groups: sham operation, unilateral ureteral obstruction (UUO), UUO/Mefunidone (25, 50, 100mg/kg/day) and UUO/PFD (500mg/kg/day). The rats were sacrificed respectively on days 3, 7, and 14 after the operation. Tubuloi...

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Mefunidone Attenuates Tubulointerstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction

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