Gugutouhuaisiyu Capsule Improves Self-Repair of Traumatic Osteonecrosis of the Femoral Head through the RUNX2 and HIF-1 alpha Pathway in Rabbits

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Ying;Zhang, Ning;Li, Jitian;Wei, Qiushi;Yuan, Qiang;...

通讯作者：

Li, WY;Wang, HB

作者机构：

[Zhang, Leilei; Li, Jitian; Cao, Xiangyang; Li, WY; Liu, Youwen; Li, Wuyin; Zhang, Ying] Luoyang Orthoped Traumatol Hosp, Orthoped Hosp Henan Prov, Med Ctr Hip, Luoyang 471002, Henan, Peoples R China.

[Wang, Haibin; Zhang, Ying] Guangzhou Univ Tradit Chinese Med, Orthopaed Lab, Guangzhou 510405, Guangdong, Peoples R China.

[Zhang, Ning] Hunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Hunan, Peoples R China.

[Wei, Qiushi; He, Wei] Guangzhou Univ Tradit Chinese Med, Inst Orthopaed, Digital Orthoped Lab, Guangzhou 510240, Guangdong, Peoples R China.

[Wei, Qiushi; He, Wei] Guangzhou Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Arthropathy, Guangzhou 510240, Guangdong, Peoples R China.

通讯机构：

[Li, WY ] L

[Wang, HB ] G

Luoyang Orthoped Traumatol Hosp, Orthoped Hosp Henan Prov, Med Ctr Hip, Luoyang 471002, Henan, Peoples R China.

Guangzhou Univ Tradit Chinese Med, Orthopaed Lab, Guangzhou 510405, Guangdong, Peoples R China.

语种：

英文

关键词：

Gugutouhuaisiyu Capsule;traumatic ONFH;RUNX2;HIF-1 alpha pathway

期刊：

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS

ISSN：

0393-974X

年：

2023

卷：

期：

页码：

1501-1509

DOI：

10.23812/j.biol.regul.homeost.agents.20233703.149

基金类别：

National Sci-ence Foundation of China [81774348, 81874477]; Science and Technology Project of Henan Province [212102310365]

机构署名：

本校为其他机构

院系归属：

研究生院

摘要：

Background: We aimed to explore the molecular mechanisms underlying the effect of Gugutouhuaisiyu Capsule (GGTHSYC) on traumatic osteonecrosis of the femoral head (ONFH) using rabbit models.Methods: New Zealand rabbits (n = 24) were randomly placed into the control, model, and 30 and 60 mg/kg GGTHSYC treatment groups. Animals in the model and GGTHSYC treatment groups were subjected to surgically induced ONFH. Rabbits in the 30 and 60 mg/kg GGTHSYC treatment groups were administered GGTHSYC via the gastrointestinal route. MRI (magnetic resonance imaging) was employed to assess osteonecrosis. Th...

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Gugutouhuaisiyu Capsule Improves Self-Repair of Traumatic Osteonecrosis of the Femoral Head through the RUNX2 and HIF-1 alpha Pathway in Rabbits

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