期刊论文

Effect of Juanbi Lijie Qing Fang(蠲痹历节清方)on rats with acute gouty arthritis and its mechanism of action

中文

中医正骨

1001-6015

2018

30

2

1-6+15

10.3969/j.issn.1001-6015.2018.02.001

国家自然科学基金面上项目（81574005）；

本校为第一机构

目的:探讨蠲痹历节清方对急性痛风性关节炎大鼠的影响及其作用机制.方法:将96只2月龄雄性清洁级健康SD大鼠随机分为正常对照组、模型组、蠲痹历节清方组、依托考昔组,每组24只.模型组、蠲痹历节清方组、依托考昔组大鼠以氧嗪酸钾溶液连续腹腔注射后,于大鼠右侧踝关节腔内注射尿酸钠溶液;正常对照组大鼠腹腔及右侧踝关节腔分别注入等剂量生理盐水.关节腔内注射后即刻给予药物干预,正常对照组和模型组以10 mL·kg-1生理盐水灌胃,蠲痹历节清方组以22 g·kg-1剂量的蠲痹历节清方悬混液灌胃,依托考昔组以5.5 mg· kg-1剂量的依托考昔悬混液灌胃;每日2次,连续灌胃2d.分别于药物干预开始后4h、12 h、24...

P=0.000,P=0.000,P=0.001,P=0.008;P=0.000,P=0.000,P=0.000,P=0.001),and was higher in model group compared to JBLJQF group and etoricoxib group(P=0.000,P=0.001,P=0.000,P=0.000;P=0.000,P=0.000,P=0.000,P=0.000).There was no statistical difference in content of TNF-αprotein in ankle synovial tissues between JBLJQF group and etoricoxib group(P=0.212,P=0.079,P=0.091,P=0.088).There was statistical difference in content of IL-1βprotein in ankle synovial tissues between the 4 groups at 4,12,24 and 48 hours after the beginning of drug intervention(3.43+/...