Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Yingjiao;Chu, Shifeng;Hu, Yaomei;Yang, Songwei;Li, Xun;...

通讯作者：

Chen, Nai-Hong

作者机构：

[Ai, Qidi; Li, Xun; Gong, Limin; Yang, Songwei; Hu, Yaomei; Wang, Huiqin; Chen, Nai-Hong; Liu, Yingjiao; Ren, Siyu] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China.

[Ai, Qidi; Li, Xun; Gong, Limin; Yang, Songwei; Hu, Yaomei; Wang, Huiqin; Chen, Nai-Hong; Liu, Yingjiao; Ren, Siyu] Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Peoples R China.

[Li, Xun; Chen, Nai-Hong; Liu, Yingjiao; Chu, Shifeng] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Li, Xun; Chen, Nai-Hong; Liu, Yingjiao; Chu, Shifeng] Peking Union Med Coll, Beijing 100050, Peoples R China.

[Chen, Nai-Hong; Zheng, Qinglian; Xu, Xin] South China Normal Univ, Inst Brain Res & Rehabil, Guangzhou 510631, Peoples R China.

通讯机构：

[Chen, Nai-Hong] H

[Chen, Nai-Hong] C

[Chen, Nai-Hong] P

[Chen, Nai-Hong] S

Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Adenosine;Gap junction protein (Cx43);Glutamate;Glutamate receptor (AMPAR);Glutamate transporter (glt-1);Oxygen glucose deprivation/reoxygenation (OGD/R)

期刊：

Cellular and Molecular Neurobiology

ISSN：

0272-4340

年：

2021

卷：

期：

页码：

687-704

DOI：

10.1007/s10571-020-00876-5

基金类别：

This work was supported by the Hunan University of Chinese Medicine First-class Disciple Construction Project (201803), Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces (2016TP2008), Hunan Provincial Natural Science Fund (S2019JJQNJJ1064), Project of NDRC and State Administration of Traditional Chinese Medicine (ZYBZH-Y-HUN-24).

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Excitatory toxicity is still a hot topic in the study of ischemic stroke, and related research has focused mainly on neurons. Adenosine is an important neuromodulator that is known as a “biosignature” in the central nervous system (CNS). The protective effect of exogenous adenosine on neurons has been confirmed, but its mechanism remains elusive. In this study, astrocytes were pretreated with adenosine, and the effects of an A2a receptor (A2aR) inhibitor (SCH58261) and A2b receptor (A2bR) inhibitor (PSB1115) on excitatory glutamate were inves...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Exogenous Adenosine Antagonizes Excitatory Amino Acid Toxicity in Primary Astrocytes

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问