High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: A potential molecular mechanism for diabetes-induced cognitive dysfunction

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成果类型：

期刊论文

作者：

Wu, Jing*;Zhou, Shan-Lei;Pi, Lin-Hua;Shi, Xia-Jie;Ma, Ling-Ran;...

通讯作者：

Wu, Jing;Wang, Shan

作者机构：

[Pi, Lin-Hua; Chen, Zi; Shi, Xia-Jie; Zhou, Shan-Lei; Qu, Min-Li; Wu, Jing; Wang, Shan] Cent S Univ, Xiang Ya Hosp, Dept Endocrinol, Changsha, Hunan, Peoples R China.

[Li, Xin; Ma, Ling-Ran; Wang, Shan] Cent S Univ, Dept Pharmaceut Engn, Coll Chem & Chem Engn, Changsha, Hunan, Peoples R China.

[Nie, Sheng-Dan] Hunan Normal Univ, Affiliated Hosp 1, Peoples Hosp Hunan Prov, Inst Clin Med, Changsha, Hunan, Peoples R China.

[Liao, Duan-Fang] Hunan Univ Tradit Chinese Med, Sch Pharm, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Pei, Jin-Jing] Karolinska Inst, KI Alzheimers Dis Res Ctr, Novum, Stockholm, Sweden.

通讯机构：

[Wu, J; Wang, S; Wang, Shan] C

Cent S Univ, Xiang Ya Hosp, Dept Endocrinol, Changsha, Hunan, Peoples R China.

Cent S Univ, Dept Pharmaceut Engn, Coll Chem & Chem Engn, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

caveolin-1;cognitive dysfunction;diabetes mellitus;mTOR;tau hyperphosphorylation

期刊：

Oncotarget

ISSN：

1949-2553

年：

2017

卷：

期：

页码：

40843-40856

DOI：

10.18632/oncotarget.17257

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170754, 81402915, 81470046, 81573480, 81670771]; Key Research and Development Program of Hunan Province [2016JC2071]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

The abnormally hyperphosphorylated tau is thought to be implicated in diabetes-associated cognitive deficits. The role of mammalian target of rapamycin (mTOR) / S6 kinase (S6K) signalling in the formation of tau hyperphosphorylation has been previously studied. Caveolin-1 (Cav-1), the essential structure protein of caveolae, promotes neuronal survival and growth, and inhibits glucose metabolism. In this study, we aimed to investigate the role of Cav-1 in the formation of tau hyperphosphorylation under chronic hyperglycemic condition (HGC). Diabetic rats were induced by streptozotocin (STZ). Pr...

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High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: A potential molecular mechanism for diabetes-induced cognitive dysfunction

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