Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity

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成果类型：

期刊论文

作者：

Jia, Yan-Zhe;Yang, Yu-Pei;Cheng, Shao-Wu;Cao, Liang;Xie, Qing-Ling;...

通讯作者：

Peng, Cai-Yun;Wang, W

作者机构：

[Jia, Yan-Zhe; Wang, Wei; Peng, Cai-Yun; Jian, Yu-Qing; Peng, CY; Li, Bin; Xie, Qing-Ling; Yang, Yu-Pei; Wang, Meng-Yun] Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.

[Cheng, Shao-Wu] Hunan Univ Chinese Med, Key Lab Coll & Univ Hunan Prov Cytobiol & Mol Bio, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China.

[Liu, Bin] Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China.

[Cao, Liang] Hunan Acad Agr Sci, Inst Agr Environm & Agroecol, Changsha 410125, Peoples R China.

通讯机构：

[Peng, CY; Wang, W ] H

Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Kadsura coccinea (Lem.) A. C. Sm.;Schisandraceae;Heilaohu;Phytochemical;Lignans;Hepatoprotective activity;Fruit

期刊：

Phytochemistry

ISSN：

0031-9422

年：

2021

卷：

184

页码：

112678

DOI：

10.1016/j.phytochem.2021.112678

基金类别：

National Natural Science Foundation of China [81374062, 81803708]; Hunan Provincial Key Laboratory of Dong Medicine [2015TP1020-02]; Hunan Science and Technology Department [2019JJ50315]; Postgraduate Scientific Research Innovation Project of Hunan Province [CX20190537, CX 2018B508]

机构署名：

本校为第一且通讯机构

院系归属：

中西医结合学院

药学院

摘要：

Phytochemical investigations on the fresh fruits of Kadsura coccinea (Lem.) A. C. Sm. have led to the isolation of fourteen undescribed 2,2'-cyclolignans named heilaohuguosus A-N, four undescribed aryltetrahydronaphthalene lignans, heilaohuguosus O-R and one tetrahydrofuran lignan, heilaohuguosu 5, with twenty-seven previously described lignan analogues. Their structures and absolute configurations of heilaohuguosus A S were established by spectroscopic methods including 1D and 2D-NMR techniques and CD experiments. All isolated compounds were evaluated for their hepatoprotective activity again...

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Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity

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