Astragalus-Scorpion Drug Pair Inhibits the Development of Prostate Cancer by Regulating GDPD4-2/PI3K/AKT/mTOR Pathway and Autophagy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

You, Xujun;Wu, Yongrong;Li, Qixin;Sheng, Wen;Zhou, Qing;...

通讯作者：

Fu, W.

作者机构：

[You, Xujun] Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.

[Li, Qixin; You, Xujun; Fu, Wei] Guangzhou Univ Chinese Med, Shenzhen Baoan Tradit Chinese Med Hosp, Dept Androl, Shenzhen, Peoples R China.

[Wu, Yongrong] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha, Peoples R China.

[Sheng, Wen] Hunan Univ Chinese Med, Androl Lab, Changsha, Peoples R China.

[Zhou, Qing] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Androl, Changsha, Peoples R China.

通讯机构：

Department of Andrology, Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China

语种：

英文

关键词：

Astragalus-Scorpio;prostate cancer;PI3K;AKT;Astragaloside IV;polypeptide extract from scorpion venom;autophagy

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2022

卷：

页码：

2067

DOI：

10.3389/fphar.2022.895696

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

中西医结合学院

研究生院

摘要：

Objective: Prostate cancer (PCa) is an epithelial malignancy of the prostate that currently lacks effective treatment. Traditional Chinese medicine (TCM) can play an anticancer role through regulating the immune system, anti-tumor angiogenesis, regulating tumor cell apoptosis, autophagy dysfunction, and other mechanisms. This study attempted to explore the active ingredients and potential mechanism of action of the Astragalus–Scorpion (A–S) drug pair in PCa, in order to provide new insights into the treatment of PCa. Methods: Network pharmaco...

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Astragalus-Scorpion Drug Pair Inhibits the Development of Prostate Cancer by Regulating GDPD4-2/PI3K/AKT/mTOR Pathway and Autophagy

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