Efficacy and safety of immunosuppressive therapy combined with eltrombopag for severe aplastic anemia: a systematic review and meta-analysis

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成果类型：

期刊论文

作者：

Zhang, Yan;Li, Jie;Li, Xi;Geng, Qianshuang;Xie, Yuqin;...

通讯作者：

Ma, YM;Wei, MX

作者机构：

[Ma, YM; Ma, Yanmei; Zhang, Yan] Changzhi Med Coll, Heji Hosp, Dept Hematol, Changzhi 046000, Shanxi, Peoples R China.

[Li, Jie] Hunan Univ Chinese Med, Liuyang Hosp Tradit Chinese Med, Dept Oncol & Hematol, Changsha 410300, Hunan, Peoples R China.

[Li, Xi] Changzhi Med Coll, Heping Hosp, Dept Nephrol, Changzhi 046000, Shanxi, Peoples R China.

[Wei, Mingxia; Wei, MX; Xie, Yuqin; Zhang, Guoxiang; Geng, Qianshuang] Changzhi Med Coll, Heping Hosp, Dept Hematol, Changzhi 046000, Shanxi, Peoples R China.

通讯机构：

[Wei, MX ; Ma, YM ] C

Changzhi Med Coll, Heji Hosp, Dept Hematol, Changzhi 046000, Shanxi, Peoples R China.

Changzhi Med Coll, Heping Hosp, Dept Hematol, Changzhi 046000, Shanxi, Peoples R China.

语种：

英文

期刊：

Systematic Reviews

ISSN：

2046-4053

年：

2024

卷：

期：

页码：

1-14

DOI：

10.1186/s13643-024-02515-2

基金类别：

This research was supported by the Key Research and Development Project of Science and Technology Department of Liuyang (K23011137) and the Heji Hospital of Changzhi Medical College “2220 Research Incubation Program” (No.202203).

机构署名：

本校为第一机构

摘要：

Immunosuppressive therapy (IST) is the first choice for severe aplastic anemia (SAA) patients with hematopoietic stem cell transplantation (HSCT) limitation, and the main factor limiting its efficacy is too few residual hematopoietic stem/progenitor cells (HSPC). Eltrombopag (EPAG), as a small molecule thrombopoietin receptor agonist, can stimulate the proliferation of residual HSPC and restore the bone marrow hematopoietic function of patients. In recent years, many studies have observed the efficacy and safety of IST combined with EPAG in the...

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Efficacy and safety of immunosuppressive therapy combined with eltrombopag for severe aplastic anemia: a systematic review and meta-analysis

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