Nicotinate-Curcumin Impedes Foam Cell Formation from THP-1 Cells through Restoring Autophagy Flux

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成果类型：

期刊论文

作者：

Gu, Hong-Feng;Li, Hai-Zhe;Tang, Ya-Ling;Tang, Xiao-Qing;Zheng, Xi-Long;...

通讯作者：

Liao, Duan-Fang

作者机构：

[Gu, Hong-Feng; Tang, Xiao-Qing; Tang, Ya-Ling] Univ South China, Dept Physiol, Hengyang, Peoples R China.

[Gu, Hong-Feng; Tang, Xiao-Qing; Tang, Ya-Ling] Univ South China, Inst Neurosci, Hengyang, Peoples R China.

[Li, Hai-Zhe] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Fac Med, Libin Cardiovasc Inst Alberta, Smooth Muscle Res Grp,Dept Biochem & Mol Biol, Calgary, AB, Canada.

[Zheng, Xi-Long; Liao, Duan-Fang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

通讯机构：

[Liao, Duan-Fang] H

Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

Autophagic cell death;Macrophages;Cholesterol;Lipids;Atherosclerosis;Cell staining;Fluorescence imaging;Lysosomes

期刊：

PLoS ONE

ISSN：

1932-6203

年：

2016

卷：

期：

页码：

e0154820-

DOI：

10.1371/journal.pone.0154820

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31371161, 81500349]; construct program of the key discipline in Hunan province, China (Basic Medicine Sciences in University of South China); Postdoctoral Science Foundation of ChinaChina Postdoctoral Science Foundation [2012M521525]; Zhengxiang Scholar Program of University of South China [2014-004]

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Our previous studies have indicated that a novel curcumin derivate nicotinate-curcumin (NC) has beneficial effects on the prevention of atherosclerosis, but the precise mechanisms are not fully understood. Given that autophagy regulates lipid metabolism, the present study was designed to investigate whether NC decreases foam cell formation through restoring autophagy flux in oxidized low-density lipoprotein (ox-LDL)-treated THP-1 cells. Our results showed that ox-LDL (100 μg/ml) was accumulated in THP-1 cells and impaired autophagy flux. Ox-LD...

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Nicotinate-Curcumin Impedes Foam Cell Formation from THP-1 Cells through Restoring Autophagy Flux

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