Eps8 promotes cellular growth of human malignant gliomas

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ding, Xiaofeng;Zhou, Fangliang（周芳亮）;Wang, Fangmei;Yang, Zijian;Zhou, Chang;...

通讯作者：

Xiang, Shuanglin

作者机构：

[Zhou, Fangliang; Zhang, Bo; Wei, Zheng; Zhang, Jian; Zhou, Chang; Xiang, Shuanglin; Wang, Fangmei; Hu, Xiang; Yang, Zijian; Wang, Guangwei; Ding, Xiaofeng; Zhou, Jianlin] Hunan Normal Univ, Key Lab Prot Chem & Dev Biol, State Educ Minist China, Coll Life Sci, Changsha 410081, Hunan, Peoples R China.

[Zhou, Fangliang; Zhang, Bo] Hunan Univ Chinese Med, Coll Basic Med Sci, Changsha, Hunan, Peoples R China.

[Yang, Junmei; Wang, Guangwei] Hunan Normal Univ, Sch Med, Changsha 410081, Hunan, Peoples R China.

[Xiang, Shuanglin] Hunan Normal Univ, Key Lab Prot Chem & Dev Biol, State Educ Minist China, Coll Life Sci, Lushan Rd 14, Changsha 410081, Hunan, Peoples R China.

通讯机构：

[Xiang, Shuanglin] H

Hunan Normal Univ, Key Lab Prot Chem & Dev Biol, State Educ Minist China, Coll Life Sci, Lushan Rd 14, Changsha 410081, Hunan, Peoples R China.

语种：

英文

关键词：

EGF receptor substrate 8;glioma;cellular growth;lentiviral RNAi system;extracellular signal-regulated protein kinase;phosphorylated serine-threonine protein kinase Akt;beta-catenin

期刊：

Oncology Reports

ISSN：

1021-335X

年：

2013

卷：

期：

页码：

697-703

DOI：

10.3892/or.2012.2160

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30900827, 81071656, 81071696, 81172112]; Key Laboratory of Protein Chemistry and Developmental Biology of the Ministry of Education, Hunan Normal University

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Eps8 was initially identified as a substrate of the epidermal growth factor receptor. Overexpression of Eps8 leads to increased mitogenic signaling and malignant transformation. However, little is known concerning the importance of Eps8 in human gliomas. In this study, we found that Eps8 was overexpressed in 56.6% of human gliomas (WHO grades III and IV) compared with adjacent normal brain tissues by immunohistochemical analysis. The U251 human glioma cell line stably expressing Eps8 was established by G418 screening, and the ectopic expression...

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Eps8 promotes cellular growth of human malignant gliomas

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