7α-Hydroxyfriedelan-3-one-26-ol-29-oic acid and other Constituents from Pileostegia viburnoides var. glabrescens

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成果类型：

期刊论文

作者：

Chen, Sheng-Huang;Yu, Juan;Li, Qin-Wen;Zhao, Jian-Ping;Wedge, David E.;...

通讯作者：

Wang, W

作者机构：

[Chen, Sheng-Huang; Wang, Wei; Yu, Juan; Liao, Duan-Fang; Li, Qin-Wen; Khan, Ikhlas A.] Hunan Univ Chinese Med, Sch Pharm, Sino Luxemburg TCM Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.

[Zhao, Jian-Ping; Khan, Ikhlas A.] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA.

[Wedge, David E.; Duke, Stephen O.] Univ Mississippi, ARS, USDA, Nat Prod Utilizat Res Unit,Natl Ctr Nat Prod Res, University, MS 38677 USA.

[Wang, Yu-Hong] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha 410208, Hunan, Peoples R China.

[Fronczek, Frank R.] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA.

通讯机构：

[Wang, W ] H

Hunan Univ Chinese Med, Sch Pharm, Sino Luxemburg TCM Res Ctr, TCM & Ethnomed Innovat & Dev Lab, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Pileostegia viburnoides var. glabrescens;Chemical constituents;Anti-inflammatory activity;Cytotoxicity;Phytotoxicity

期刊：

Natural Product Communications

ISSN：

1934-578X

年：

2016

卷：

期：

页码：

931-934

DOI：

10.1177/1934578x1601100716

基金类别：

Changsha Science and Technology Bureau Project [80010369, K1205019-31]; Hunan Province University Innovation Platform Open Fund Project [12K086, 13K077]; Himan Key Laboratory of Chinese Materia Medica Powder and Innovative Drugs Established by Provincial and Ministry [ZYFT201402]; Division of Stem Cell University of Chinese Medicine; Chinese Materia Medica, Hunan University of Chinese Medicine

机构署名：

本校为第一且通讯机构

院系归属：

药学院

摘要：

Phytochemical investigation of the roots and rhizomes of Pileostegia viburnoides var. glabrescens led to the isolation and identification of 31 compounds (1-31), 25 of which (1-2, 4-7, 9-12, 15-18, 21-31) were isolated from the Pileostegia genus for the first time. 7α-Hydroxyfriedelan-3-one-26-ol-29-oic acid (1) is a new friedelane-Type triterpene. The structure of n-butyl-β-D-fructopyranoside (2) was determined by single-crystal X-ray diffraction. Compounds 4 and 12 displayed marginal cytotoxicity against the P388 murine leukemia cell line w...

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7α-Hydroxyfriedelan-3-one-26-ol-29-oic acid and other Constituents from Pileostegia viburnoides var. glabrescens

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