期刊论文

Simultaneous determination and migration of four anti-oxidants in five-layer co-extrusion films used for infusion

中文

药物评价研究

1674-6376

2012

35

5

354-358

本校为第一机构

目的 建立同时测定抗氧化剂1010、330、168、1076的高效液相色谱法(HPLC),测定五层共挤膜输液用膜中的4种抗氧化剂,并研究抗氧化剂向0.9％氯化钠注射液中的迁移情况.方法 采用RP-HPLC方法,色谱柱为伊利特C18柱(250mm×4.6 mm,5 μm),乙腈-四氢呋喃-水(63∶30∶7)为流动相,柱温30℃,体积流量1 mL/min;检测波长276 nm,进样量10 μL.结果 抗氧化剂1010、330、168、1076分别在0.6～253.6、0.6～246.4、0.6～257.6、0.6～251.6 μg/mL线性关系良好,平均回收率分别为90.70％ (RSD=2.35％)、89.11％ (RSD=2.75％)、89.87％ (RSD=3.01％)、92.78％ (RSD=1.81％).同时测定五层共挤膜输液用膜中的抗氧化剂...

Objective To establish a high performance liquid chromatography method for simultaneous determination of anti-oxidants 1010,330,168,and 1076 in five-layer co-extrusion films used for infusion,and to study the migration of anti-oxidants to 0.9% sodium chloride injection.Methods The study was carried out by using RP-HPLC with Yilite C18 column（250 mm × 4.6 mm,5 μm） and acetonitrile-tetrahydrofuran-water（63：30：7） as mobile phase.The column temperature was 30 ℃,flow rate was 1 mL/min,detection wavelength was 276 nm,and injection volume was...