期刊论文

Effect of Sini Powder on non-alcoholic fatty hepatocirrhosis induced by methionine-choline deficit diet

中文

药物评价研究

1674-6376

2014

37

3

231-234

10.7501/j.issn.1674-6376.2014.03.009

本校为第一机构

目的研究四逆散对蛋氨酸-胆碱缺乏（methionine-choline-deficient,MCD）饮食诱导的小鼠非酒精性脂肪肝炎的作用及机制。方法通过MCD饮食诱导小鼠非酒精性脂肪肝炎模型,并同时预防性给药普罗布考及四逆散4周,HE染色观察各组小鼠肝组织病理改变;检测小鼠血清丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）、三酰甘油（TG）、含量以及肝脏组织TG、丙二醛（MDA）含量和超氧化物歧化酶（SOD）活力。结果四逆散高剂量组小鼠血清ALT、AST均有下降,血清中TG含量升高,且肝脏TG含量降低;病理观察显示四逆散高剂量组小鼠肝细胞内脂肪空泡减少,炎性细胞浸润减少;同时肝组织SOD活力增加,MDA含量降低。...

Objective To study the effect of Sini Powder on non-alcoholic fatty hepatocirrhosis（NASH） induced by methionine- choline deficit（MCD） diet. Methods The model mice of NASH were administered with probucol and Sini Powder for 4 weeks. Then the pathological changes of liver were observed by HE staining, the contents of ALT, AST, TG, and MDA and the activity of SOD were tested and compared among groups. Results Compared with the model group, the ALT and AST contents in serum were lower, TG content in serum was reduced, and TG content in liver wa...